Diet and Exercise Reverse Leptin Resistance. By Dr. Mercola. Leptin, a hormone that plays a key role in regulating energy intake and energy expenditure, may be one of the most important hormones in your body that will determine your health and lifespan. ![]() Insulin is another, and the two work in tandem. Both insulin and leptin resistance are associated with obesity, and impairment of their ability to transfer the information to receptors is the true foundational core of most all chronic degenerative diseases. Metabolism can roughly be defined as the chemistry that turns food into life, and therefore insulin and leptin are both critical to health and disease. Insulin and leptin work together to control the quality of your metabolism, and, to a significant extent, your rate of metabolism. By acquiring a better understanding of how leptin and its receptor interact, researchers now believe they will be able to find new treatments for obesity and other metabolic disorders such as type 2 diabetes, as well as inflammatory diseases like rheumatoid arthritis and psoriasis. According to recent research published in the journal Molecular Cell,1 the leptin receptor has two hinged legs that swivel until they come in contact with leptin. Once leptin attaches to the receptor, these legs stop swiveling and become rigid, thereby sending a signal to an enzyme called Janus kinase,2 which has the ability to bind inflammatory cytokines. It is believed that inhibiting the Janus kinases might help improve inflammatory and metabolic disorders. Alan Saltiel, Director of the Life Sciences Institute, told Medical News Today: 3. Since leptin is a master regulator of appetite, understanding why resistance to its effects develops in obesity has been a major obstacle to discovering new drugs for obesity and diabetes. Developing a clear picture of how leptin can bind to its receptor may be the first step in overcoming leptin resistance. That's the only way the medical industry can make money. However, the way to correct leptin resistance has nothing to do with drugs, and everything to do with diet. But first.. What Exactly is Leptin? Leptin is a very powerful and influential hormone produced by your fat cells. Your fat, by way of leptin, tells your brain whether you should be hungry, eat and make more fat, whether you should reproduce, or (partly by controlling insulin) whether to engage in maintenance and repair. In short, leptin is the way that your fat stores speak to your brain to let your brain know how much energy is available and, very importantly, what to do with it. Therefore, leptin may be on top of the food chain in metabolic importance and relevance to disease. ![]()
![]() ![]() If your leptin signaling is working properly, when your fat stores are . Controlling hunger is a major (though not the only) way that leptin controls energy storage. Hunger is a very powerful, ancient, and deep- seated drive that, if stimulated long enough, will make you eat and store more energy. The only way to eat less in the long- term is to not be hungry, and the only way to do this is to control the hormones that regulate hunger, the primary one being leptin. How Do You Become Leptin Resistant? You become leptin- resistant by the same general mechanism that you become insulin- resistant – by continuous overexposure to high levels of the hormone. If you eat a diet that is high in sugar (particularly fructose), grains, and processed foods – the same type of diet that will also increase inflammation in your body – as the sugar gets metabolized in your fat cells, the fat releases surges in leptin. Over time, if your body is exposed to too much leptin, it will become resistant, just as your body can become resistant to insulin. The only known way to reestablish proper leptin (and insulin) signaling is to prevent those surges, and the only known way to do that is via diet. ![]() ![]() As such, diet can have a more profound effect on your health than any other known modality of medical treatment. A strategic whole food diet, as detailed in my free nutrition plan, that emphasizes good fats and avoids blood sugar spikes coupled with targeted supplements will enhance insulin and leptin sensitivity so that your brain can once again hear the feedback signals from these hormones. Obesity Helps Spur Cancer's Growth, New Study Suggests. Leptin and insulin resistance is front and center of the issue of obesity, which is now a problem of epic proportions as it increases your risk for a wide variety of other serious diseases. Anxiety and depression are among the most common conditions cited by those seeking treatment with complementary and alternative therapies, such as exercise. Remedies for Indigestion. Indigestion remedies are linked with several factors, so you will have to consciously make some lifestyle changes along with the use of. Eat Smart to Lift Mind and Body. No specific foods treat depression, but a healthy diet can be part of an overall treatment plan. Build your meals and snacks around. Leptin, a hormone that plays a key role in regulating energy intake and energy expenditure, may be one of the most important hormones in your body. ![]() ![]() At least 2. 0 different diseases and conditions are directly attributable to being overweight. This societal problem has emerged in just the past four decades, in large part due to sorely misguided dietary guidelines. One disease related to excess weight is cancer. ![]() And according to recent research, being obese promotes the growth of existing tumors regardless of diet, which may help explain why lean cancer patients often have better outcomes than their obese counterparts. The animal study, published in the Oct. Cancer Research,4 showed that tumors in obese mice grew much faster than in lean mice eating the same diet. According to the authors. When transplanted into mice, adipose stromal cells can serve as perivascular adipocyteprogenitors that promote tumor growth, perhaps helping explain the obesity- cancer link. Once these cells come across a tumor, some of them help provide oxygen and nutrients to the tumor, thereby feeding the growth of the cancer. Lead researcher Mikhail Kolonin told Medicine. Net: 5. We have shown that not only are they present, but they are also functional and affect tumor growth. Identifying the signals that cause these cells to be recruited to tumors and finding ways to block them might provide a new avenue of cancer treatment. Again, the focus is on developing drug treatments to convert cancer- boosting . If you hinge your health and well- being on that, you're likely going to miss the boat and join the ranks of cancer statistics. Research has shown that certain groups of people tend to have more brown fat than others, and there are direct correlations between the activation of brown fat and metabolic measures of good health. For example: Slender people have more brown fat than obese people do Younger people have more brown fat than elderly people, and People with normal blood sugar levels have more brown fat than those with high blood sugar So is there a way to convert harmful white fat into health promoting brown fat, without using a drug? Yes, there is. In one mouse study, the animals converted white fat into brown fat simply by exercising. The study, published in the journal Disease Models and Mechanisms. May 2. 01. 2 found that, during exercise, the animals' muscles released an enzyme called irisin, which triggered the conversion white fat cells to brown. Another study published in Nature,7 also suggests irisin may be a key to explaining the therapeutic benefits of exercise on metabolic disease. The authors write. Irisin is induced with exercise in mice and humans, and mildly increased irisin levels in the blood cause an increase in energy expenditure in mice with no changes in movement or food intake. This results in improvements in obesity and glucose homeostasis. But the answer lies not in a pill. To reverse insulin and leptin resistance: Avoid, sugar, fructose, grains, and processed foods Eat a healthful diet of whole foods, ideally organic, and replace the grain carbs with. No- to- low sugar and grain carbs. Low- to- moderate amount of protein As much highly quality healthful fat as you want (saturated and monosaturated). Most people need upwards of 5. Good sources include coconut and coconut oil, avocados, butter, nuts, and animal fats. Also take a high- quality source of animal- based omega- 3 fat, such as krill oil Similarly, while researchers investigate the pharmaceutical avenues to convert white fat cells to brown in an effort to reduce the potential for cancer growth, other research has already shown that this can likely be achieved through exercise. As I've said before, about 8. For maximum benefits, you'll want to make sure to include high- intensity interval training, which is at the heart of my Peak Fitness program. To learn more, please see my previous article: The Major Exercise Mistake I Made for Over 3. Symptoms, Causes, Treatment & Diet. You get indigestion from a disorder in the digestive tract, when the stomach acid flows back up the oesophagus. This makes the stomach lining sore and irritated and hence the pain and heartburn. In this condition, the valve or the sphincter at the top of the stomach does not function efficiently. It is called the gastro- oesophageal reflux disease (GORD). Underlying medical conditions like peptic ulcers, abnormalities in the bile ducts or pancreas, and in rare cases stomach cancer can lead to dyspepsia. To find the exact causes of indigestion, doctors may require blood and stool samples for testing, X rays and an endoscopy with biopsies to analyze the causes. Decreasing stress levels and making certain lifestyle changes can bring you relief from the condition. Symptoms of Indigestion. Indigestion is something that almost all of us have experienced at some point, yet it's never easy to describe or summarize the experience. The most characteristic indigestion symptom would be the feeling of uneasiness and a fullness in your chest and stomach soon after your meals, although sometimes there can be a delay between indigestion and eating or drinking. Heartburn is the next indicator of indigestion and involves a strong pain behind the breastbone (sternum) when digestive acids escape from stomach, travelling up the esophagus or gullet. Heartburn isn't necessarily accompanied by vomiting, but at times it may be. The other indicators are bloating and belching, and burping. Indigestion in the elderly can be accompanied by more serious health problems. You should seek medical advice if you are over 5. The following are some of the additional health disorders that should be treated immediately if they occur with chronic indigestion in old age: You unintentionally lose a lot of weight, find it difficult to swallow (dysphagia) and have persistent vomiting. If you have vomited blood or have passed stools with blood, you have gastrointestinal bleeding (bleeding in the stomach and intestines) that needs immediate medical attention. This condition will make you feel dizzy and tired. If you suffer from iron deficiency anemia (where the red blood cell count decreases because the body lacks the iron needed to produce them) and suffer from fatigue, irregular heartbeat and breathlessness, you should get yourself checked. Chronic or recurring indigestion should be checked through an endoscopy procedure for any lumps that may have formed inside the stomach. Chronic and recurring indigestion in elderly people along with the above stated conditions can be a cause of concern because in some cases these are indications of a stomach cancer. Causes of Indigestion. There are various possible causes for indigestion and dyspepsia. Indigestion causes are from digestive tract disorders like gastroesophageal reflux disease (GERD) and other abnormal conditions in the stomach. Indigestion can be triggered by conditions in the stomach such as irregularities in the pancreas or bile ducts, peptic ulcers in your duodenum and in worst cases, stomach cancer. However, since the conditions are inter related, the symptoms of indigestion improves if these conditions are treated and resolved. Peptic ulcers occur when the lining of either the stomach or the first part of your small bowel, called the duodenum is damaged and becomes inflamed. There is a mucus layer in your stomach, esophagus and bowel walls that act as a protection against the strong stomach acids that acts on the food, helps digest it and protect it from infection. When this mucus layer gets disturbed, or is damaged; the strong stomach acids irritate the tissues underneath. Peptic ulcers are caused by a bacterium that lives in the mucus layer of the stomach, called Helicobacter pylori (H. A part of the stomach or sphincter slides up to your chest cavity when you have hiatus hernia, and this causes reflux. Pregnancy increases the levels of female hormones progesterone and estrogen in the body. These hormones relax the sphincter muscles causing indigestion and heartburns in pregnant women. There is a category of indigestion, called functional dyspepsia where the indigestion occurs in the body without any cause. It is thought to affect the area where the small intestine meets the stomach. The indigestion may be because of abnormalities or a disorder in motility. Motility is the squeezing and relaxing action of the muscles in the stomach when it receives, digests and pushes the food into the small intestine. Indigestion is a side effect of certain medications like aspirin and anti- inflammatory medicines needed to treat arthritis. Indigestion causes can be linked with its remedies if you can make certain lifestyle changes. Some of the trigger symptoms of indigestion are too much smoking, intake of excessive alcohol and anxiety and stress. You can control indigestion by avoiding these. Certain pleasure foods like chocolates and caffeine relax the sphincter at the joint of the oessophagus and stomach and directly irritate the lining of the oesophagus. Obesity or being overweight increases the pressure on your stomach and make you feel like you are suffering from indigestion. Regular exercises and a walk after your meals help in settling the food down and reduce reflux. Remedies for Indigestion. Indigestion remedies are linked with several factors, so you will have to consciously make some lifestyle changes along with the use of appropriate medications to get rid of your indigestion. There are several home remedies for indigestion that can help relieve the condition, some of which have been backed by scientific studies. Refrain from smoking or from consuming aerated drinks, coffee and alcohol. Eat in small quantities throughout the day and avoid fatty foods that are hard to digest. Stop using medications that aggravate the condition by irritating the stomach lining; like aspirin and anti- inflammatory drugs. If any such medications are being used to treat an existing condition, consult with your doctor for alternatives. Avoid emotional and physical stress. You can take up physical or meditative practices to combat stress, such as yoga or even swimming. Get enough sleep at night and try to rest as much as possible during the day. According to many natural health enthusiasts some of these home remedies for indigestion could help. Like many other claims from natural health enthusiasts however, many of these are not subjected to rigorous testing and may prove ineffective. Drink half a glass of pineapple juice after eating. Apply an ice bag over your stomach, half an hour after eating. Add two spoons of coriander juice to a glass of buttermilk and drink when dealing with indigestion. Mix a spoon of lemon and ginger juice and two spoons of honey with lukewarm water and drink the concoction. Drink a cup of ginger tea after meals to avoid heartburn and nausea. Chewing a fresh garlic clove with some salt five to ten minutes before eating stimulates digestion. You may be prescribed over the counter medicines and antacids as acid indigestion treatment. These medications will provide you with acid indigestion relief by helping the stomach move food rapidly into the small intestine. You should not use these nonprescription medications over a length of time without consulting your doctor. The concept of the antacids is to combine three different salts, calcium, aluminum and magnesium with hydroxide and bicarbonate ions to neutralize the acid in the stomach. Antacids have side effects and can cause diarrhea or constipation. H2 receptor antagonists, known as H2. RAs are famotidine (Pepcid), nizatidine (Axid), ranitidine (Zantac) and cimetidine (Tagamet). H2. RAs reduce stomach acids and work slowly in improving digestion. The side effects include constipation, diarrhea, unusual bleeding or bruising and, vomiting, headache or nausea. Proton pump inhibitors (PPIs) are rabeprazole (Aciphex), omeprazole (Prilosec, Zegerid), lansoprazole (Prevacid), esomeprazole (Nexium) and pantoprazole (Protonix). PPIs are stronger than H2. RAs and treat indigestion by reducing stomach acid. PPIs are most effective in treating people suffering from GERD. Side effects of PPIs are abdominal pain, back pain, cough, dizziness, gas, nausea, vomiting, headache, constipation, and diarrhea. Prokinetics like metoclopramide (Reglan) is used to treat people who have problems with the stomach emptying too slowly. This medicine also improves the muscle action in the digestive tract. Prokinetics however have several side effects that limit its usefulness. Sleepiness, fatigue, anxiety, involuntary muscle spasms or movements and depression. Diet for Indigestion. Dietary considerations are particularly relevant in the treatment of indigestions, as this directly influences the condition. You need follow a strict diet and incorporate some eating habits if you want to get rid of indigestion. Eat lots of fruits. Fruits should be included in your diet in the whole form and processed juices avoided since they are more acidic. However, avoid acidic foods like citrus fruits, onions, tomatoes if these trigger off heartburns. You should avoid all junk foods, fatty, fried foods, spicy foods like pickles, curries and so on. You should walk at least thirty minutes in a day. However, you should not indulge in any rigorous physical activity immediately after your meal. A brisk walk at night after your meal will help with digestion. Try and maintain regularity with your meal times, and serve yourself smaller portions. Heavy meals are typically a lot harder to digest. Kids are always told to chew their food thoroughly and this bit of advice is just as important to all of us. Digestion begins the minute you begin chewing, because the food is being broken up and your saliva begins to work on it. Referencesvan Nieuw Amerongen A, Veerman EC. Ned Tijdschr Tandheelkd. Nov; 1. 02(1. 1): 4. Pub. Med PMID: 1. Try to eat a diet of natural whole foods such as fruits.. Since he is vomiting he..
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